منابع مشابه
MicroRNA gene expression deregulation in human breast cancer.
MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Indeed, miRNA aberrant expression has been previously found in human chronic lymphocytic leukemias, where miRNA signatures were associated with specif...
متن کاملDeregulation of miR-21 and miR-155 and their putative targets after silibinin treatment in T47D breast cancer cells
Objective(s):MicroRNAs (miRNAs) are a class of short RNAs that control the biological processes including cell proliferation, apoptosis and development. Aberrant expression of miRNAs was determined in the different stages of tumor development and metastasis. To study the effect of silibinin on miRNAs expression, we evaluated quantitative expression of miR-21 and miR-155 as two oncomiRs and seve...
متن کاملDeregulation of splicing factors and breast cancer development.
It is well known that many genes implicated in the development and progression of breast cancer undergo aberrant alternative splicing events to produce proteins with pro-cancer properties. These changes in alternative splicing can arise from mutations or single-nucleotide polymorphisms (SNPs) within the DNA sequences of cancer-related genes, which can strongly affect the activity of splicing fa...
متن کاملDeregulation of RGS17 Expression Promotes Breast Cancer Progression
OBJECTIVE A high level of RGS17 expression is observed in diverse human cancers and correlates with tumor progression. Herein, we aim to investigate its expression and function in breast cancer. METHODS The expression of RGS17 was detected by immunohistochemical analysis and western blot analysis. The level of miR-32 expression was investigated by qRT-PCR. Western blot analysis was used to de...
متن کاملBreast Cancer in Men
Male breast cancer is one of the rare malignancies. Clinically it usually a fixed mass in the breast in the seventh decade of life. Metabolic disorders and gynecomastia and Klinefelter's syndrome are important predisr,osing factors. Primary management is simple mastectomy plus regio:ial lymph node irradiation. In late cases or metastatic disease, orchidectomy, adrenalectomy, and hypophysec...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2020
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.15140